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cAMP-GEFII is a direct target of cAMP in regulated exocytosis.

Nature cell biology | Nov 22, 2000

http://www.ncbi.nlm.nih.gov/pubmed/11056535

Although cAMP is well known to regulate exocytosis in many secretory cells, its direct target in the exocytotic machinery is not known. Here we show that cAMP-GEFII, a cAMP sensor, binds to Rim (Rab3-interacting molecule, Rab3 being a small G protein) and to a new isoform, Rim2, both of which are putative regulators of fusion of vesicles to the plasma membrane. We also show that cAMP-GEFII, through its interaction with Rim2, mediates cAMP-induced, Ca2+-dependent secretion that is not blocked by an inhibitor of cAMP-dependent protein kinase (PKA). Accordingly, cAMP-GEFII is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, PKA-independent exocytosis.

Pubmed ID: 11056535 RIS Download

Mesh terms: Animals | Base Sequence | COS Cells | Carrier Proteins | Cercopithecus aethiops | Cyclic AMP | Cyclic AMP Receptor Protein | Cyclic AMP-Dependent Protein Kinases | DNA, Complementary | Exocytosis | GTP-Binding Proteins | Mice | Molecular Sequence Data | Nerve Tissue Proteins | Rats

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