• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were outwardly identical to wild-type littermates. FXR/BAR null mice were distinguished from wild-type mice by elevated serum bile acid, cholesterol, and triglycerides, increased hepatic cholesterol and triglycerides, and a proatherogenic serum lipoprotein profile. FXR/BAR null mice also had reduced bile acid pools and reduced fecal bile acid excretion due to decreased expression of the major hepatic canalicular bile acid transport protein. Bile acid repression and induction of cholesterol 7alpha-hydroxylase and the ileal bile acid binding protein, respectively, did not occur in FXR/BAR null mice, establishing the regulatory role of FXR/BAR for the expression of these genes in vivo. These data demonstrate that FXR/BAR is critical for bile acid and lipid homeostasis by virtue of its role as an intracellular bile acid sensor.

Pubmed ID: 11030617


  • Sinal CJ
  • Tohkin M
  • Miyata M
  • Ward JM
  • Lambert G
  • Gonzalez FJ



Publication Data

September 15, 2000

Associated Grants


Mesh Terms

  • Animals
  • Bile Acids and Salts
  • Biological Transport
  • Cholesterol 7-alpha-Hydroxylase
  • Cholesterol, Dietary
  • DNA-Binding Proteins
  • Female
  • Gene Expression
  • Homeostasis
  • Liver
  • Male
  • Mice
  • Mice, Knockout
  • RNA, Messenger
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • Triglycerides