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Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells.

Although mutations of the breast cancer susceptibility gene 1 (BRCA1) may play important roles in breast and prostate cancers, the detailed mechanism linking the functions of BRCA1 to these two hormone-related tumors remains to be elucidated. Here, we report that BRCA1 interacts with androgen receptor (AR) and enhances AR target genes, such as p21((WAF1/CIP1)), that may result in the increase of androgen-induced cell death in prostate cancer cells. The BRCA1-enhanced AR transactivation can be further induced synergistically with AR coregulators, such as CBP, ARA55, and ARA70. Together, these data suggest that the BRCA1 may function as an AR coregulator and play positive roles in androgen-induced cell death in prostate cancer cells and other androgen/AR target organs.

Pubmed ID: 11016951


  • Yeh S
  • Hu YC
  • Rahman M
  • Lin HK
  • Hsu CL
  • Ting HJ
  • Kang HY
  • Chang C


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

October 10, 2000

Associated Grants

  • Agency: NCI NIH HHS, Id: CA55639
  • Agency: NCI NIH HHS, Id: CA71570
  • Agency: NCI NIH HHS, Id: T32 CA09363D

Mesh Terms

  • Androgens
  • BRCA1 Protein
  • Cell Death
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • Glutathione Transferase
  • Humans
  • Male
  • Prostatic Neoplasms
  • Receptors, Androgen
  • Transcriptional Activation