Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

The protooncogene TCL1 is an Akt kinase coactivator.

Molecular cell | Aug 28, 2000

http://www.ncbi.nlm.nih.gov/pubmed/10983986

Human T cell prolymphocytic leukemia can result from chromosomal translocations involving 14q32.1 or Xq28 regions. The regions encode a family of protooncogenes (TCL1, MTCP1, and TCL1b) of unknown function. In yeast two-hybrid screening, we found that TCL1 interacts with Akt. All TCL1 isoforms bind to the Akt pleckstrin homology domain. Both in vitro and in vivo TCL1 increases Akt kinase activity and as a consequence enhances substrate phosphorylation. In vivo, TCL1 stabilizes the mitochondrial transmembrane potential and enhances cell proliferation and survival. In vivo, TCL1 forms trimers, which associate with Akt. TCL1 facilitates the oligomerization and activation of Akt. Our data show that TCL1 is a novel Akt kinase coactivator, which promotes Akt-induced cell survival and proliferation.

Pubmed ID: 10983986 RIS Download

Mesh terms: Animals | Binding Sites | Calcium-Calmodulin-Dependent Protein Kinases | Carrier Proteins | Cell Death | Cell Division | Cell Line | Chromosomes, Human, Pair 14 | Cloning, Molecular | Glycogen Synthase Kinase 3 | Humans | Intracellular Membranes | Lymphocyte Activation | Membrane Potentials | Mitochondria | Protein-Serine-Threonine Kinases | Proto-Oncogene Proteins | Proto-Oncogene Proteins c-akt | Proto-Oncogenes | Recombinant Proteins | Spodoptera | T-Lymphocytes | Transfection | Translocation, Genetic | Tumor Cells, Cultured | X Chromosome | bcl-Associated Death Protein | src Homology Domains

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.