Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone.

Molecular cell | Aug 28, 2000

http://www.ncbi.nlm.nih.gov/pubmed/10983970

Baculoviral IAP repeat proteins (BIRPs) may affect cell death, cell division, and tumorigenesis. The C. elegans BIRP BIR-1 was localized to chromosomes and to the spindle midzone. Embryos and fertilized oocytes lacking BIR-1 had defects in chromosome behavior, spindle midzone formation, and cytokinesis. We observed indistinguishable defects in fertilized oocytes and embryos lacking the Aurora-like kinase AIR-2. AIR-2 was not present on chromosomes in the absence of BIR-1. Histone H3 phosphorylation and HCP-1 staining, which marks kinetochores, were reduced in the absence of either BIR-1 or AIR-2. We propose that BIR-1 localizes AIR-2 to chromosomes and perhaps to the spindle midzone, where AIR-2 phosphorylates proteins that affect chromosome behavior and spindle midzone organization. The human BIRP survivin, which is upregulated in tumors, could partially substitute for BIR-1 in C. elegans. Deregulation of bir-1 promotes changes in ploidy, suggesting that similar deregulation of mammalian BIRPs may contribute to tumorigenesis.

Pubmed ID: 10983970 RIS Download

Mesh terms: Animals | Aurora Kinase B | Aurora Kinases | Caenorhabditis elegans | Caenorhabditis elegans Proteins | Cell Cycle | Cell Division | Chromosome Mapping | Chromosomes | Embryo, Nonmammalian | Female | Genes, Helminth | Helminth Proteins | Humans | Inhibitor of Apoptosis Proteins | Male | Microtubule-Associated Proteins | Molecular Sequence Data | Neoplasm Proteins | Oocytes | Protein-Serine-Threonine Kinases | Proteins | Spermatozoa | Spindle Apparatus

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

WormBase (Data, Gene Expression)

GO (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.