• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1.

Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts. Moreover, osteoblast differentiation, but not proliferation, was enhanced and osteoclastogenesis was also elevated in vitro. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions.

Pubmed ID: 10973316


  • Jochum W
  • David JP
  • Elliott C
  • Wutz A
  • Plenk H
  • Matsuo K
  • Wagner EF


Nature medicine

Publication Data

September 6, 2000

Associated Grants


Mesh Terms

  • Animals
  • Calcinosis
  • Cell Differentiation
  • Mice
  • Mice, Transgenic
  • Osteoblasts
  • Osteosclerosis
  • Phenotype
  • Proto-Oncogene Proteins c-fos