• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice.

The Ca(2+)/calmodulin-dependent protein kinase type IV/Gr (CaMKIV/Gr) is a key effector of neuronal Ca(2+) signaling; its function was analyzed by targeted gene disruption in mice. CaMKIV/Gr-deficient mice exhibited impaired neuronal cAMP-responsive element binding protein (CREB) phosphorylation and Ca(2+)/CREB-dependent gene expression. They were also deficient in two forms of synaptic plasticity: long-term potentiation (LTP) in hippocampal CA1 neurons and a late phase of long-term depression in cerebellar Purkinje neurons. However, despite impaired LTP and CREB activation, CaMKIV/Gr-deficient mice exhibited no obvious deficits in spatial learning and memory. These results support an important role for CaMKIV/Gr in Ca(2+)-regulated neuronal gene transcription and synaptic plasticity and suggest that the contribution of other signaling pathways may spare spatial memory of CaMKIV/Gr-deficient mice.

Pubmed ID: 10964952

Authors

  • Ho N
  • Liauw JA
  • Blaeser F
  • Wei F
  • Hanissian S
  • Muglia LM
  • Wozniak DF
  • Nardi A
  • Arvin KL
  • Holtzman DM
  • Linden DJ
  • Zhuo M
  • Muglia LJ
  • Chatila TA

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

September 1, 2000

Associated Grants

None

Mesh Terms

  • Animals
  • Brain
  • Calcium Signaling
  • Calcium-Calmodulin-Dependent Protein Kinase Type 4
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Cerebral Cortex
  • Cyclic AMP Response Element-Binding Protein
  • Electric Stimulation
  • Hippocampus
  • Long-Term Potentiation
  • Male
  • Maze Learning
  • Memory
  • Mice
  • Mice, Knockout
  • Motor Activity
  • Neuronal Plasticity
  • Neurons
  • Posture
  • Purkinje Cells
  • Pyramidal Cells
  • Reverse Transcriptase Polymerase Chain Reaction
  • Swimming
  • Synapses