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Act1, an NF-kappa B-activating protein.

Use of an NF-kappaB-dependent selectable marker facilitated the isolation of a cell line containing a cDNA encoding Act1, an NF-kappaB activator. Act1 associates with and activates IkappaB kinase (IKK), leading to the liberation of NF-kappaB from its complex with IkappaB. Many signaling pathways that liberate NF-kappaB also activate activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). Act1 also activates JNK, suggesting that it might be part of a multifunctional complex involved in the activation of both NF-kappaB and JNK. Act1 fails to activate NF-kappaB in an IL-1-unresponsive mutant cell line in which all known signaling components are present, suggesting that it interacts with an unknown component in IL-1 signaling.

Pubmed ID: 10962024 RIS Download

Mesh terms: Adaptor Proteins, Signal Transducing | Amino Acid Sequence | Carrier Proteins | Cell Line | DNA, Complementary | Enzyme Activation | Helix-Loop-Helix Motifs | Humans | Interleukin-1 | JNK Mitogen-Activated Protein Kinases | Mitogen-Activated Protein Kinases | Molecular Sequence Data | NF-kappa B | Recombinant Proteins | Sequence Homology, Nucleic Acid | Trans-Activators | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins

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Associated grants

  • Agency: NCI NIH HHS, Id: P01 CA062220
  • Agency: NIGMS NIH HHS, Id: R01 GM060020
  • Agency: NCI NIH HHS, Id: CA62220
  • Agency: NIGMS NIH HHS, Id: GM60020

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