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Act1, an NF-kappa B-activating protein.

Use of an NF-kappaB-dependent selectable marker facilitated the isolation of a cell line containing a cDNA encoding Act1, an NF-kappaB activator. Act1 associates with and activates IkappaB kinase (IKK), leading to the liberation of NF-kappaB from its complex with IkappaB. Many signaling pathways that liberate NF-kappaB also activate activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). Act1 also activates JNK, suggesting that it might be part of a multifunctional complex involved in the activation of both NF-kappaB and JNK. Act1 fails to activate NF-kappaB in an IL-1-unresponsive mutant cell line in which all known signaling components are present, suggesting that it interacts with an unknown component in IL-1 signaling.

Pubmed ID: 10962024


  • Li X
  • Commane M
  • Nie H
  • Hua X
  • Chatterjee-Kishore M
  • Wald D
  • Haag M
  • Stark GR


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

September 12, 2000

Associated Grants

  • Agency: NCI NIH HHS, Id: CA62220
  • Agency: NIGMS NIH HHS, Id: GM60020

Mesh Terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Carrier Proteins
  • Cell Line
  • DNA, Complementary
  • Enzyme Activation
  • Helix-Loop-Helix Motifs
  • Humans
  • Interleukin-1
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinases
  • Molecular Sequence Data
  • NF-kappa B
  • Recombinant Proteins
  • Sequence Homology, Nucleic Acid
  • Trans-Activators
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins