Act1, an NF-kappa B-activating protein.
Use of an NF-kappaB-dependent selectable marker facilitated the isolation of a cell line containing a cDNA encoding Act1, an NF-kappaB activator. Act1 associates with and activates IkappaB kinase (IKK), leading to the liberation of NF-kappaB from its complex with IkappaB. Many signaling pathways that liberate NF-kappaB also activate activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). Act1 also activates JNK, suggesting that it might be part of a multifunctional complex involved in the activation of both NF-kappaB and JNK. Act1 fails to activate NF-kappaB in an IL-1-unresponsive mutant cell line in which all known signaling components are present, suggesting that it interacts with an unknown component in IL-1 signaling.
Pubmed ID: 10962024
- Li X
- Commane M
- Nie H
- Hua X
- Chatterjee-Kishore M
- Wald D
- Haag M
- Stark GR
Proceedings of the National Academy of Sciences of the United States of America
September 12, 2000
- Agency: NCI NIH HHS, Id: CA62220
- Agency: NIGMS NIH HHS, Id: GM60020
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Carrier Proteins
- Cell Line
- DNA, Complementary
- Enzyme Activation
- Helix-Loop-Helix Motifs
- JNK Mitogen-Activated Protein Kinases
- Mitogen-Activated Protein Kinases
- Molecular Sequence Data
- NF-kappa B
- Recombinant Proteins
- Sequence Homology, Nucleic Acid
- Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
- Psoriasis susceptibility 13 is related to genes TRAF3IP2, C6orf5, ACT1, CIKS, C6orf4, C6orf6, PSORS13, CANDF8.
- Candidiasis, familial, 8 is related to genes TRAF3IP2, C6orf5, ACT1, CIKS, C6orf4, C6orf6, PSORS13, CANDF8 which are autosomal recessive according to the OMIM database.