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The domineering non-autonomy of frizzled and van Gogh clones in the Drosophila wing is a consequence of a disruption in local signaling.

Mechanisms of development | Sep 14, 2000

http://www.ncbi.nlm.nih.gov/pubmed/10960784

The frizzled (fz) gene is required for the development of distally pointing hairs on the Drosophila wing. It has been suggested that fz is needed for the propagation of a signal along the proximal distal axis of the wing. The directional domineering non-autonomy of fz clones could be a consequence of a failure in the propagation of this signal. We have tested this hypothesis in two ways. In one set of experiments we used the domineering non-autonomy of fz and Vang Gogh (Vang) clones to assess the direction of planar polarity signaling in the wing. prickle (pk) mutations alter wing hair polarity in a cell autonomous way, so pk cannot be altering a global polarity signal. However, we found that pk mutations altered the direction of the domineering non-autonomy of fz and Vang clones, arguing that this domineering non-autonomy is not due to an alteration in a global signal. In a second series of experiments we ablated cells in the pupal wing. We found that a lack of cells that could be propagating a long-range signal did not alter hair polarity. We suggest that fz and Vang clones result in altered levels of a locally acting signal and the domineering non-autonomy results from wild-type cells responding to this abnormal signal.

Pubmed ID: 10960784 RIS Download

Mesh terms: Alleles | Animals | Body Patterning | DNA-Binding Proteins | Drosophila | Drosophila Proteins | Frizzled Receptors | Genes, Insect | LIM Domain Proteins | Membrane Proteins | Models, Biological | Mosaicism | Mutation | Pupa | Receptors, G-Protein-Coupled | Signal Transduction | Wing

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM37136
  • Agency: NICHD NIH HHS, Id: HD07528

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