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The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation.

Molecular cell | Jul 31, 2000

http://www.ncbi.nlm.nih.gov/pubmed/10949024

The C/EBP transcription factor, Slbo, is required for migration of border cells during Drosophila oogenesis. Unexpectedly, we find that neither increase nor decrease of Slbo activity is tolerated in border cells. Correct protein level is in part ensured by cell type-specific regulated turnover of Slbo protein. Through genetic screening, we identify two genes that are involved in this regulation. The Ubp64 ubiquitin hydrolase acts as a stabilizer of Slbo protein. A novel gene, tribbles, is a negative regulator of slbo in vivo. Tribbles acts by specifically targeting Slbo for rapid degradation via ubiquitination.

Pubmed ID: 10949024 RIS Download

Mesh terms: Animals | CCAAT-Enhancer-Binding Proteins | Cell Cycle Proteins | Cell Movement | DNA-Binding Proteins | Down-Regulation | Drosophila | Drosophila Proteins | Female | Genes, Insect | Insect Proteins | Nuclear Proteins | Oogenesis | Protein-Serine-Threonine Kinases | Transcription Factors | Ubiquitins

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