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A time-less function for mouse timeless.

The timeless (tim) gene is essential for circadian clock function in Drosophila melanogaster. A putative mouse homolog, mTimeless (mTim), has been difficult to place in the circadian clock of mammals. Here we show that mTim is essential for embryonic development, but does not have substantiated circadian function.

Pubmed ID: 10903565


  • Gotter AL
  • Manganaro T
  • Weaver DR
  • Kolakowski LF
  • Possidente B
  • Sriram S
  • MacLaughlin DT
  • Reppert SM


Nature neuroscience

Publication Data

August 15, 2000

Associated Grants

  • Agency: NIMH NIH HHS, Id: MH12117
  • Agency: NINDS NIH HHS, Id: R01NS39303
  • Agency: NICHD NIH HHS, Id: R37HD14427

Mesh Terms

  • Animals
  • CLOCK Proteins
  • Cell Cycle Proteins
  • Chimera
  • Circadian Rhythm
  • Genes, Reporter
  • Heterozygote
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Luciferases
  • Mice
  • Mice, Inbred Strains
  • Mice, Knockout
  • Molecular Sequence Data
  • Mutagenesis, Site-Directed
  • Phylogeny
  • Recombinant Proteins
  • Spodoptera
  • Suprachiasmatic Nucleus
  • Trans-Activators
  • Transcription Factors
  • Transcription, Genetic
  • Transfection