Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.

Science (New York, N.Y.) | Jul 7, 2000

http://www.ncbi.nlm.nih.gov/pubmed/10884224

Loss of cell polarity and tissue architecture are characteristics of malignant cancers derived from epithelial tissues. We provide evidence from Drosophila that a group of membrane-associated proteins act in concert to regulate both epithelial structure and cell proliferation. Scribble (Scrib) is a cell junction-localized protein required for polarization of embryonic and, as demonstrated here, imaginal disc and follicular epithelia. We show that the tumor suppressors lethal giant larvae (lgl) and discs-large (dlg) have identical effects on all three epithelia, and that scrib also acts as a tumor suppressor. Scrib and Dlg colocalize and overlap with Lgl in epithelia; activity of all three genes is required for cortical localization of Lgl and junctional localization of Scrib and Dlg. scrib, dlg, and lgl show strong genetic interactions. Our data indicate that the three tumor suppressors act together in a common pathway to regulate cell polarity and growth control.

Pubmed ID: 10884224 RIS Download

Mesh terms: Animals | Cell Division | Cell Membrane | Cell Polarity | Cell Transformation, Neoplastic | Cytoplasm | Drosophila | Drosophila Proteins | Embryo, Nonmammalian | Epidermis | Epithelial Cells | Female | Genes, Insect | Genes, Tumor Suppressor | Insect Proteins | Intercellular Junctions | Membrane Proteins | Morphogenesis | Mutation | Phenotype | Tumor Suppressor Proteins

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

GO (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.