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Impaired cued and contextual memory in NPAS2-deficient mice.

Science (New York, N.Y.) | Jun 23, 2000

Neuronal PAS domain protein 2 (NPAS2) is a basic helix-loop-helix (bHLH) PAS domain transcription factor expressed in multiple regions of the vertebrate brain. Targeted insertion of a beta-galactosidase reporter gene (lacZ) resulted in the production of an NPAS2-lacZ fusion protein and an altered form of NPAS2 lacking the bHLH domain. The neuroanatomical expression pattern of NPAS2-lacZ was temporally and spatially coincident with formation of the mature frontal association/limbic forebrain pathway. NPAS2-deficient mice were subjected to a series of behavioral tests and were found to exhibit deficits in the long-term memory arm of the cued and contextual fear task. Thus, NPAS2 may serve a dedicated regulatory role in the acquisition of specific types of memory.

Pubmed ID: 10864874 RIS Download

Mesh terms: Animals | Avoidance Learning | Basic Helix-Loop-Helix Transcription Factors | Behavior, Animal | Brain | Conditioning (Psychology) | Cues | Fear | Gene Targeting | Helix-Loop-Helix Motifs | Learning | Limbic System | Male | Memory | Mice | Nerve Tissue Proteins | Prosencephalon | Recombinant Fusion Proteins | Touch | Transcription Factors | Transcriptional Activation | Transfection | beta-Galactosidase

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Associated grants

  • Agency: NIA NIH HHS, Id: AG12297
  • Agency: NIA NIH HHS, Id: AG16450
  • Agency: NINDS NIH HHS, Id: NS01763

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