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Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast.

Science (New York, N.Y.) | Jun 23, 2000

http://www.ncbi.nlm.nih.gov/pubmed/10864871

Mammalian kinetochores contain the centromere-specific histone H3 variant CENP-A, whose incorporation into limited chromosomal regions may be important for centromere function and chromosome segregation during mitosis. However, regulation of CENP-A localization and its role have not been clear. Here we report that the fission yeast homolog SpCENP-A is essential for establishing centromere chromatin associated with equal chromosome segregation. SpCENP-A binding to the nonrepetitious inner centromeres depended on Mis6, an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is likely required for recruiting SpCENP-A to form proper connection of sister centromeres.

Pubmed ID: 10864871 RIS Download

Mesh terms: Amino Acid Sequence | Cell Cycle | Cell Cycle Proteins | Centromere | Chromatin | Chromosomal Proteins, Non-Histone | Chromosome Segregation | DNA Replication | DNA, Fungal | Fungal Proteins | G1 Phase | Histones | Mitosis | Molecular Sequence Data | Mutation | Recombinant Fusion Proteins | S Phase | Schizosaccharomyces | Schizosaccharomyces pombe Proteins | Temperature

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