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Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control.

Science (New York, N.Y.) | Jun 9, 2000

http://www.ncbi.nlm.nih.gov/pubmed/10846167

Theories of the regulation of cognition suggest a system with two necessary components: one to implement control and another to monitor performance and signal when adjustments in control are needed. Event-related functional magnetic resonance imaging and a task-switching version of the Stroop task were used to examine whether these components of cognitive control have distinct neural bases in the human brain. A double dissociation was found. During task preparation, the left dorsolateral prefrontal cortex (Brodmann's area 9) was more active for color naming than for word reading, consistent with a role in the implementation of control. In contrast, the anterior cingulate cortex (Brodmann's areas 24 and 32) was more active when responding to incongruent stimuli, consistent with a role in performance monitoring.

Pubmed ID: 10846167 RIS Download

Mesh terms: Adolescent | Adult | Brain Mapping | Cerebral Cortex | Cognition | Color | Female | Humans | Magnetic Resonance Imaging | Male | Prefrontal Cortex | Reading

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