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BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis.

CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addition to attracting B cells, BLC expression led to development of lymph node-like structures that contained B and T cell zones, high endothelial venules, stromal cells, and the chemokine SLC. Development of these features was strongly dependent on B lymphocytes and on lymphotoxin alpha1beta2 and could be reversed by blocking lymphotoxin alpha1beta2. These findings establish that BLC is sufficient to activate a pathway of events leading to formation of organized lymphoid tissue.

Pubmed ID: 10843380

Authors

  • Luther SA
  • Lopez T
  • Bai W
  • Hanahan D
  • Cyster JG

Journal

Immunity

Publication Data

May 20, 2000

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI45073

Mesh Terms

  • Animals
  • B-Lymphocytes
  • Chemotactic Factors
  • Islets of Langerhans
  • Lymphoid Tissue
  • Lymphotoxin-alpha
  • Mice
  • Mice, Transgenic
  • Receptors, CXCR5
  • Receptors, Chemokine
  • Receptors, Cytokine