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Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.

http://www.ncbi.nlm.nih.gov/pubmed/10799849

We have identified new activating receptors of the Ig superfamily expressed on human myeloid cells, called TREM (triggering receptor expressed on myeloid cells). TREM-1 is selectively expressed on blood neutrophils and a subset of monocytes and is up-regulated by bacterial LPS. Engagement of TREM-1 triggers secretion of IL-8, monocyte chemotactic protein-1, and TNF-alpha and induces neutrophil degranulation. Intracellularly, TREM-1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-gamma. To mediate activation, TREM-1 associates with the transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses.

Pubmed ID: 10799849 RIS Download

Mesh terms: Adaptor Proteins, Signal Transducing | Amino Acid Sequence | Biological Markers | Calcium Signaling | Chemokines | Cytokines | Fungi | Gram-Negative Bacteria | Gram-Positive Bacteria | Humans | Immunoglobulins | Inflammation | Macrophage Activation | Membrane Glycoproteins | Membrane Proteins | Molecular Sequence Data | Molecular Weight | Monocytes | Multigene Family | Neutrophil Activation | Neutrophils | Phosphorylation | Receptors, Immunologic | Tyrosine | Up-Regulation

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