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Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors.

A protein named nuclear receptor binding factor-2 (NRBF-2) was identified by yeast two-hybrid screening, as an interaction partner of peroxisome proliferator-activated receptor alpha as well as several other nuclear receptors. NRBF-2 exhibited a gene activation function, when tethered to a heterologous DNA binding domain, in both mammalian cells and yeast.

Pubmed ID: 10786636


  • Yasumo H
  • Masuda N
  • Furusawa T
  • Tsukamoto T
  • Sadano H
  • Osumi T


Biochimica et biophysica acta

Publication Data

January 31, 2000

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Gene Expression Regulation
  • Liver
  • Molecular Sequence Data
  • Plasmids
  • Rats
  • Receptors, Cell Surface
  • Receptors, Cytoplasmic and Nuclear
  • Sequence Alignment
  • Trans-Activators
  • Transcription Factors
  • Transcriptional Activation
  • Tumor Cells, Cultured