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Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.

Cell | Mar 31, 2000

http://www.ncbi.nlm.nih.gov/pubmed/10778858

We present evidence that Rb forms a repressor containing histone deacetylase (HDAC) and the hSWI/SNF nucleosome remodeling complex, which inhibits transcription of genes for cyclins E and A and arrests cells in the G1 phase of the cell cycle. Phosphorylation of Rb by cyclin D/cdk4 disrupts association with HDAC, relieving repression of the cyclin E gene and G1 arrest. However, the Rb-hSWI/SNF complex persists and is sufficient to maintain repression of the cyclin A and cdc2 genes, inhibiting exit from S phase. HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF then appear to maintain the order of cyclin E and A expression during the cell cycle, which in turn regulates exit from G1 and from S phase, respectively.

Pubmed ID: 10778858 RIS Download

Mesh terms: Binding Sites | CDC2-CDC28 Kinases | Carrier Proteins | Cell Cycle | Cell Division | Cyclin A | Cyclin D | Cyclin E | Cyclin-Dependent Kinase 2 | Cyclin-Dependent Kinase 4 | Cyclin-Dependent Kinase Inhibitor p16 | Cyclin-Dependent Kinases | Cyclins | DNA Helicases | Enzyme Inhibitors | G1 Phase | Histone Deacetylase Inhibitors | Histone Deacetylases | Humans | Hydroxamic Acids | Nuclear Proteins | Phosphorylation | Promoter Regions, Genetic | Protein-Serine-Threonine Kinases | Proto-Oncogene Proteins | Repressor Proteins | Retinoblastoma Protein | S Phase | Transcription Factors | Transcription, Genetic | Transfection | Tumor Cells, Cultured

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