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Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.

We present evidence that Rb forms a repressor containing histone deacetylase (HDAC) and the hSWI/SNF nucleosome remodeling complex, which inhibits transcription of genes for cyclins E and A and arrests cells in the G1 phase of the cell cycle. Phosphorylation of Rb by cyclin D/cdk4 disrupts association with HDAC, relieving repression of the cyclin E gene and G1 arrest. However, the Rb-hSWI/SNF complex persists and is sufficient to maintain repression of the cyclin A and cdc2 genes, inhibiting exit from S phase. HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF then appear to maintain the order of cyclin E and A expression during the cell cycle, which in turn regulates exit from G1 and from S phase, respectively.

Pubmed ID: 10778858

Authors

  • Zhang HS
  • Gavin M
  • Dahiya A
  • Postigo AA
  • Ma D
  • Luo RX
  • Harbour JW
  • Dean DC

Journal

Cell

Publication Data

March 31, 2000

Associated Grants

None

Mesh Terms

  • Binding Sites
  • CDC2-CDC28 Kinases
  • Carrier Proteins
  • Cell Cycle
  • Cell Division
  • Cyclin A
  • Cyclin D
  • Cyclin E
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclin-Dependent Kinases
  • Cyclins
  • DNA Helicases
  • Enzyme Inhibitors
  • G1 Phase
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases
  • Humans
  • Hydroxamic Acids
  • Nuclear Proteins
  • Phosphorylation
  • Promoter Regions, Genetic
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Retinoblastoma Protein
  • S Phase
  • Transcription Factors
  • Transcription, Genetic
  • Transfection
  • Tumor Cells, Cultured