Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2.

Nature genetics | Apr 4, 2000

http://www.ncbi.nlm.nih.gov/pubmed/10742109

Corticotropin-releasing hormone (Crh), a 41-residue polypeptide, activates two G-protein-coupled receptors, Crhr1 and Crhr2, causing (among other transductional events) phosphorylation of the transcription factor Creb. The physiologic role of these receptors is only partially understood. Here we report that male, but not female, Crhr2-deficient mice exhibit enhanced anxious behaviour in several tests of anxiety in contrast to mice lacking Crhr1. The enhanced anxiety of Crhr2-deficient mice is not due to changes in hypothalamic-pituitary-adrenal (HPA) axis activity, but rather reflects impaired responses in specific brain regions involved in emotional and autonomic function, as monitored by a reduction of Creb phosphorylation in male, but not female, Crhr2-/- mice. We propose that Crhr2 predominantly mediates a central anxiolytic response, opposing the general anxiogenic effect of Crh mediated by Crhr1. Neither male nor female Crhr2-deficient mice show alterations of baseline feeding behaviour. Both respond with increased edema formation in response to thermal exposure, however, indicating that in contrast to its central role in anxiety, the peripheral role of Crhr2 in vascular permeability is independent of gender.

Pubmed ID: 10742109 RIS Download

Mesh terms: Adrenocorticotropic Hormone | Animals | Anxiety | Anxiety Disorders | Brain | Corticosterone | Corticotropin-Releasing Hormone | Cyclic AMP Response Element-Binding Protein | Edema | Feeding Behavior | Female | Gene Deletion | Hot Temperature | Hypothalamo-Hypophyseal System | Injections, Intraventricular | Male | Maze Learning | Mice | Mice, Inbred C57BL | Mice, Knockout | Motor Activity | Phosphorylation | Pituitary-Adrenal System | Proto-Oncogene Proteins c-fos | Receptors, Corticotropin-Releasing Hormone | Restraint, Physical | Sex Factors | Stress, Physiological | Weight Gain

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.