Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present these in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.
Pubmed ID: 10721995 RIS Download
Mesh terms: Antigens, CD4 | CD4-Positive T-Lymphocytes | Cell Adhesion Molecules | Cell Movement | Cells, Cultured | Cervix Uteri | Coculture Techniques | Dendritic Cells | Female | HIV Envelope Protein gp120 | HIV Infections | HIV-1 | Humans | Lectins | Lymph Nodes | Lymphoid Tissue | Macromolecular Substances | Male | Mucous Membrane | Receptors, CCR5 | Receptors, HIV | Rectum | Transfection | Uterus
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