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Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction.

The roles of phosphoinositide 3-kinase (PI3K) and phospholipase C (PLC) in chemoattractant-elicited responses were studied in mice lacking these key enzymes. PI3Kgamma was required for chemoattractant-induced production of phosphatidylinositol 3,4,5-trisphosphate [PtdIns (3,4,5)P3] and has an important role in chemoattractant-induced superoxide production and chemotaxis in mouse neutrophils and in production of T cell-independent antigen-specific antibodies composed of the immunoglobulin lambda light chain (TI-IglambdaL). The study of the mice lacking PLC-beta2 and -beta3 revealed that the PLC pathways have an important role in chemoattractant-mediated production of superoxide and regulation of protein kinases, but not chemotaxis. The PLC pathways also appear to inhibit the chemotactic activity induced by certain chemoattractants and to suppress TI-IglambdaL production.

Pubmed ID: 10669417

Authors

  • Li Z
  • Jiang H
  • Xie W
  • Zhang Z
  • Smrcka AV
  • Wu D

Journal

Science (New York, N.Y.)

Publication Data

February 11, 2000

Associated Grants

None

Mesh Terms

  • Animals
  • B-Lymphocytes
  • Chemokine CCL4
  • Chemotactic Factors
  • Chemotaxis, Leukocyte
  • Immunoglobulin lambda-Chains
  • Isoenzymes
  • Macrophage Inflammatory Proteins
  • Mice
  • N-Formylmethionine Leucyl-Phenylalanine
  • Neutrophil Infiltration
  • Neutrophils
  • Peritonitis
  • Phosphatidylinositol 3-Kinases
  • Phosphatidylinositol Phosphates
  • Phospholipase C beta
  • Phosphorylation
  • Signal Transduction
  • Skin Ulcer
  • Superoxides
  • Type C Phospholipases