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Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction.

Science (New York, N.Y.) | Feb 11, 2000

http://www.ncbi.nlm.nih.gov/pubmed/10669417

The roles of phosphoinositide 3-kinase (PI3K) and phospholipase C (PLC) in chemoattractant-elicited responses were studied in mice lacking these key enzymes. PI3Kgamma was required for chemoattractant-induced production of phosphatidylinositol 3,4,5-trisphosphate [PtdIns (3,4,5)P3] and has an important role in chemoattractant-induced superoxide production and chemotaxis in mouse neutrophils and in production of T cell-independent antigen-specific antibodies composed of the immunoglobulin lambda light chain (TI-IglambdaL). The study of the mice lacking PLC-beta2 and -beta3 revealed that the PLC pathways have an important role in chemoattractant-mediated production of superoxide and regulation of protein kinases, but not chemotaxis. The PLC pathways also appear to inhibit the chemotactic activity induced by certain chemoattractants and to suppress TI-IglambdaL production.

Pubmed ID: 10669417 RIS Download

Mesh terms: Animals | B-Lymphocytes | Chemokine CCL4 | Chemotactic Factors | Chemotaxis, Leukocyte | Immunoglobulin lambda-Chains | Isoenzymes | Macrophage Inflammatory Proteins | Mice | N-Formylmethionine Leucyl-Phenylalanine | Neutrophil Infiltration | Neutrophils | Peritonitis | Phosphatidylinositol 3-Kinases | Phosphatidylinositol Phosphates | Phospholipase C beta | Phosphorylation | Signal Transduction | Skin Ulcer | Superoxides | Type C Phospholipases

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