Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia.
Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. To further study the in vivo function of VEGF-B, we have generated Vegfb knockout mice (Vegfb(-/-)). Unlike Vegfa knockout mice, which die during embryogenesis, Vegfb(-/-) mice are healthy and fertile. Despite appearing overtly normal, Vegfb(-/-) hearts are reduced in size and display vascular dysfunction after coronary occlusion and impaired recovery from experimentally induced myocardial ischemia. These findings reveal a role for VEGF-B in the development or function of coronary vasculature and suggest potential clinical use in therapeutic angiogenesis.
Pubmed ID: 10666423 RIS Download
Aging | Animals | Animals, Newborn | Coronary Vessel Anomalies | Coronary Vessels | Endothelial Growth Factors | Female | Heart | Heart Defects, Congenital | Immunohistochemistry | Male | Mice | Mice, Knockout | Myocardial Ischemia | Myocardium | Vascular Endothelial Growth Factor B