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Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia.

Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. To further study the in vivo function of VEGF-B, we have generated Vegfb knockout mice (Vegfb(-/-)). Unlike Vegfa knockout mice, which die during embryogenesis, Vegfb(-/-) mice are healthy and fertile. Despite appearing overtly normal, Vegfb(-/-) hearts are reduced in size and display vascular dysfunction after coronary occlusion and impaired recovery from experimentally induced myocardial ischemia. These findings reveal a role for VEGF-B in the development or function of coronary vasculature and suggest potential clinical use in therapeutic angiogenesis.

Pubmed ID: 10666423

Authors

  • Bellomo D
  • Headrick JP
  • Silins GU
  • Paterson CA
  • Thomas PS
  • Gartside M
  • Mould A
  • Cahill MM
  • Tonks ID
  • Grimmond SM
  • Townson S
  • Wells C
  • Little M
  • Cummings MC
  • Hayward NK
  • Kay GF

Journal

Circulation research

Publication Data

February 4, 2000

Associated Grants

None

Mesh Terms

  • Aging
  • Animals
  • Animals, Newborn
  • Coronary Vessel Anomalies
  • Coronary Vessels
  • Endothelial Growth Factors
  • Female
  • Heart
  • Heart Defects, Congenital
  • Immunohistochemistry
  • Male
  • Mice
  • Mice, Knockout
  • Myocardial Ischemia
  • Myocardium
  • Vascular Endothelial Growth Factor B