Maintenance has been completed and SciCrunch services have been restored. We apologize for any inconvenience it may have caused.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia.

Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. To further study the in vivo function of VEGF-B, we have generated Vegfb knockout mice (Vegfb(-/-)). Unlike Vegfa knockout mice, which die during embryogenesis, Vegfb(-/-) mice are healthy and fertile. Despite appearing overtly normal, Vegfb(-/-) hearts are reduced in size and display vascular dysfunction after coronary occlusion and impaired recovery from experimentally induced myocardial ischemia. These findings reveal a role for VEGF-B in the development or function of coronary vasculature and suggest potential clinical use in therapeutic angiogenesis.

Pubmed ID: 10666423

Authors

  • Bellomo D
  • Headrick JP
  • Silins GU
  • Paterson CA
  • Thomas PS
  • Gartside M
  • Mould A
  • Cahill MM
  • Tonks ID
  • Grimmond SM
  • Townson S
  • Wells C
  • Little M
  • Cummings MC
  • Hayward NK
  • Kay GF

Journal

Circulation research

Publication Data

February 4, 2000

Associated Grants

None

Mesh Terms

  • Aging
  • Animals
  • Animals, Newborn
  • Coronary Vessel Anomalies
  • Coronary Vessels
  • Endothelial Growth Factors
  • Female
  • Heart
  • Heart Defects, Congenital
  • Immunohistochemistry
  • Male
  • Mice
  • Mice, Knockout
  • Myocardial Ischemia
  • Myocardium
  • Vascular Endothelial Growth Factor B