Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

Science (New York, N.Y.) | Jan 28, 2000

http://www.ncbi.nlm.nih.gov/pubmed/10650002

Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which activate chaperone genes in response to ER stress, also activated JNK, and IRE1alpha-/- fibroblasts were impaired in JNK activation by ER stress. The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. Dominant-negative TRAF2 inhibited activation of JNK by IRE1. Activation of JNK by endogenous signals initiated in the ER proceeds by a pathway similar to that initiated by cell surface receptors in response to extracellular signals.

Pubmed ID: 10650002 RIS Download

Mesh terms: Animals | Cell Line | Cells, Cultured | Endoplasmic Reticulum | Endoribonucleases | Enzyme Activation | Gene Targeting | Humans | JNK Mitogen-Activated Protein Kinases | Membrane Proteins | Mitogen-Activated Protein Kinases | Multienzyme Complexes | Protein Kinases | Protein-Serine-Threonine Kinases | Proteins | Rats | Recombinant Fusion Proteins | TNF Receptor-Associated Factor 2 | Thapsigargin | Two-Hybrid System Techniques | eIF-2 Kinase

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIDDK NIH HHS, Id: DK47119
  • Agency: NIEHS NIH HHS, Id: ES08681

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.