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Requirement of CD9 on the egg plasma membrane for fertilization.

Science (New York, N.Y.) | Jan 14, 2000

http://www.ncbi.nlm.nih.gov/pubmed/10634791

CD9 is an integral membrane protein associated with integrins and other membrane proteins. Mice lacking CD9 were produced by homologous recombination. Both male and female CD9-/- mice were born healthy and grew normally. However, the litter size from CD9-/- females was less than 2% of that of the wild type. In vitro fertilization experiments indicated that the cause of this infertility was due to the failure of sperm-egg fusion. When sperm were injected into oocytes with assisted microfertilization techniques, however, the fertilized eggs developed to term. These results indicate that CD9 has a crucial role in sperm-egg fusion.

Pubmed ID: 10634791 RIS Download

Mesh terms: Animals | Antigens, CD | Antigens, CD9 | Cell Membrane | Crosses, Genetic | Embryonic and Fetal Development | Female | Fertilization | Fertilization in Vitro | Gene Targeting | Infertility, Female | Integrin alpha6beta1 | Integrins | Litter Size | Male | Membrane Glycoproteins | Mice | Mice, Inbred C57BL | Oocytes | Ovulation | Sperm-Ovum Interactions