Absence of striatal volume differences between depressed subjects with no comorbid medical illness and matched comparison subjects.
OBJECTIVE: The striatum (caudate and putamen) appears to be important in the pathogenesis of depression. Some studies show smaller than normal striatal structure volumes in depressed subjects. This study compared striatal volumes in depressed and nondepressed women, screened to exclude major cerebrovascular disease risk factors and comorbid medical illness. METHOD: Caudate and putamen volumes were measured from magnetic resonance imaging scans of 24 depressed women and 24 matched nondepressed comparison subjects. RESULTS: Caudate and putamen volumes were not significantly different between depressed and nondepressed groups. CONCLUSIONS: These findings differ from those of previous studies, possibly because of the exclusion of subjects with cerebrovascular risk factors in this study.
SciCrunch is a data sharing and display platform. Anyone can create a custom portal where they can select searchable subsets of hundreds of data sources, brand their web pages and create their community. SciCrunch will push data updates automatically to all portals on a weekly basis. User communities can also add their own data to scicrunch, however this is not currently a free service.