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Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations.

http://www.ncbi.nlm.nih.gov/pubmed/10587360

The cause of many autoimmune and inflammatory diseases is unresolved, although dysregulated production of tumor necrosis factor (TNF) family members appears to be important in many cases. BAFF, a new member of the TNF family, binds to B cells and costimulates their growth in vitro. Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti-DNA autoantibodies, and immunoglobulin deposition in the kidneys. This phenotype is reminiscent of certain human autoimmune disorders and suggests that dysregulation of BAFF expression may be a critical element in the chain of events leading to autoimmunity.

Pubmed ID: 10587360 RIS Download

Mesh terms: Animals | Antibodies, Antinuclear | Autoantibodies | Autoimmune Diseases | B-Cell Activating Factor | B-Lymphocytes | Flow Cytometry | Humans | Immunoglobulin A | Immunoglobulin G | Immunoglobulin M | Immunoglobulins | Kidney | Kinetics | Leukocyte Count | Lung | Lymphatic Diseases | Membrane Proteins | Mice | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Rheumatoid Factor | T-Lymphocytes | Tumor Necrosis Factor-alpha

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Mouse Genome Informatics (Data, Gene Annotation)

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