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Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40).

CD134 (OX40) is a member of the TNF receptor family that is expressed on activated T lymphocytes. T cells from mice that lack expression of CD134 made strong responses to a range of challenges, but they showed impaired proliferation in response to direct stimulation through the TCR with monoclonal anti-CD3epsilon Ab. CD134-deficient mice controlled infection with Leishmania major, Nippostrongylus brasiliensis, and Theiler's murine encephalomyelitis virus, and they made overtly normal Ab responses to a variety of antigens. Thus, CD134 is not essential for many T cell responses in vivo, nor is it required for the provision of help to B cells. Nonetheless, a subtle role in the regulation of T cell reactivity is suggested by the effect of CD134 deficiency on in vitro T cell responses.

Pubmed ID: 10586044

Authors

  • Pippig SD
  • Peña-Rossi C
  • Long J
  • Godfrey WR
  • Fowell DJ
  • Reiner SL
  • Birkeland ML
  • Locksley RM
  • Barclay AN
  • Killeen N

Journal

Journal of immunology (Baltimore, Md. : 1950)

Publication Data

December 15, 1999

Associated Grants

None

Mesh Terms

  • Animals
  • Antibodies, Helminth
  • Antibodies, Protozoan
  • Antigens, CD27
  • B-Lymphocytes
  • Female
  • Gene Targeting
  • Immunity, Cellular
  • Leishmania major
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Mice, Mutant Strains
  • Nippostrongylus
  • Receptors, OX40
  • Receptors, Tumor Necrosis Factor
  • T-Lymphocytes