Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40).
CD134 (OX40) is a member of the TNF receptor family that is expressed on activated T lymphocytes. T cells from mice that lack expression of CD134 made strong responses to a range of challenges, but they showed impaired proliferation in response to direct stimulation through the TCR with monoclonal anti-CD3epsilon Ab. CD134-deficient mice controlled infection with Leishmania major, Nippostrongylus brasiliensis, and Theiler's murine encephalomyelitis virus, and they made overtly normal Ab responses to a variety of antigens. Thus, CD134 is not essential for many T cell responses in vivo, nor is it required for the provision of help to B cells. Nonetheless, a subtle role in the regulation of T cell reactivity is suggested by the effect of CD134 deficiency on in vitro T cell responses.
Pubmed ID: 10586044 RIS Download
Animals | Antibodies, Helminth | Antibodies, Protozoan | Antigens, CD27 | B-Lymphocytes | Female | Gene Targeting | Immunity, Cellular | Leishmania major | Lymphocyte Activation | Mice | Mice, Inbred BALB C | Mice, Inbred C57BL | Mice, Inbred CBA | Mice, Mutant Strains | Nippostrongylus | Receptors, OX40 | Receptors, Tumor Necrosis Factor | T-Lymphocytes