Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1).

Genes & development | Nov 15, 1999

http://www.ncbi.nlm.nih.gov/pubmed/10580009

The p16(INK4a) tumor suppressor inhibits cyclin-dependent kinases (CDK4 and CDK6). Here we report the isolation of a novel gene, SEI-1, whose product (p34(SEI-1)) appears to antagonize the function of p16(INK4a). Addition of p34(SEI-1) to cyclin D1-CDK4 renders the complex resistant to inhibition by p16(INK4a). Expression of SEI-1 is rapidly induced on addition of serum to quiescent fibroblasts, and ectopic expression of p34(SEI-1) enables fibroblasts to proliferate even in low serum concentrations. p34(SEI-1) seems to act as a growth factor sensor and may facilitate the formation and activation of cyclin D-CDK complexes in the face of inhibitory levels of INK4 proteins.

Pubmed ID: 10580009 RIS Download

Mesh terms: Animals | Blood Physiological Phenomena | COS Cells | Carrier Proteins | Cell Cycle | Cells, Cultured | Cercopithecus aethiops | Chromosomes, Human, Pair 19 | Culture Media, Serum-Free | Cyclin-Dependent Kinase 4 | Cyclin-Dependent Kinase Inhibitor p16 | Cyclin-Dependent Kinases | DNA, Complementary | Enzyme Activation | Fibroblasts | Genes | HeLa Cells | Humans | Nuclear Proteins | Proto-Oncogene Proteins | Saccharomyces cerevisiae | Trans-Activators | Transfection | Two-Hybrid System Techniques

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.