Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen.

Our previous studies in both mouse and human identified the Bapx1 homeobox gene, a member of the NK gene family, as one of the earliest markers for prechondrogenic cells that will subsequently undergo mesenchymal condensation, cartilage production and, finally, endochondral bone formation. In addition, Bapx1 is an early developmental marker for splanchnic mesoderm, consistent with a role in visceral mesoderm specification, a function performed by its homologue bagpipe, in Drosophila. The human homologue of Bapx1 has been identified and mapped to 4p16.1, a region containing loci for several skeletal diseases. Bapx1 null mice are affected by a perinatal lethal skeletal dysplasia and asplenia, with severe malformation or absence of specific bones of the vertebral column and cranial bones of mesodermal origin, with the most severely affected skeletal elements corresponding to ventral structures associated with the notochord. We provide evidence that the failure of the formation of skeletal elements in Bapx1 null embryos is a consequence of a failure of cartilage development, as demonstrated by downregulation of several molecular markers required for normal chondroblast differentiation (&agr; 1(II) collagen, Fgfr3, Osf2, Indian hedgehog, Sox9), as well as a chondrocyte-specific alpha1 (II) collagen-lacZ transgene. The cartilage defects are correlated with failed differentiation of the sclerotome at the time when these cells are normally initiating chondrogenesis. Loss of Bapx1 is accompanied by an increase in apoptotic cell death in affected tissues, although cell cycling rates are unaltered.

Pubmed ID: 10572046 RIS Download

Mesh terms: Animals | Bone Development | Bone Morphogenetic Protein 4 | Bone Morphogenetic Proteins | Cartilage, Articular | Collagen | Core Binding Factor Alpha 1 Subunit | DNA-Binding Proteins | Female | Gene Expression Regulation, Developmental | Gene Targeting | Genes, Homeobox | Hedgehog Proteins | Homeodomain Proteins | Humans | Male | Mice | Mice, Inbred C57BL | Mice, Transgenic | Neoplasm Proteins | Paired Box Transcription Factors | Protein-Tyrosine Kinases | Proteins | Receptor, Fibroblast Growth Factor, Type 3 | Receptors, Fibroblast Growth Factor | Spine | Spleen | Trans-Activators | Transcription Factors

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: Telethon, Id: D.075

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.