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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Immunity | Oct 23, 1999

Toll-like receptor (TLR) 2 and TLR4 are implicated in the recognition of various bacterial cell wall components, such as lipopolysaccharide (LPS). To investigate in vivo roles of TLR2, we generated TLR2-deficient mice. In contrast to LPS unresponsiveness in TLR4-deficient mice, TLR2-deficient mice responded to LPS to the same extent as wild-type mice. TLR2-deficient macrophages were hyporesponsive to several Gram-positive bacterial cell walls as well as Staphylococcus aureus peptidoglycan. TLR4-deficient macrophages lacked the response to Gram-positive lipoteichoic acids. These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition.

Pubmed ID: 10549626 RIS Download

Mesh terms: Animals | Antigens, Bacterial | Cell Wall | Corynebacterium diphtheriae | Drosophila Proteins | Escherichia coli | Female | Gram-Negative Bacteria | Gram-Positive Bacteria | Interleukin-1 Receptor-Associated Kinases | Lipid A | Lipopolysaccharides | Macrophages, Peritoneal | Male | Membrane Glycoproteins | Mice | Mice, Inbred C57BL | Mice, Knockout | NF-kappa B | Nocardia | Peptidoglycan | Protein Isoforms | Protein Kinases | Receptors, Cell Surface | Salmonella | Signal Transduction | Species Specificity | Staphylococcus aureus | Teichoic Acids | Toll-Like Receptor 2 | Toll-Like Receptor 4 | Toll-Like Receptors

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Associated grants


Mouse Genome Informatics (Data, Gene Annotation)

Gene Ontology (Data, Gene Annotation)

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