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A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila.

Molecular cell | Oct 26, 1999

http://www.ncbi.nlm.nih.gov/pubmed/10549280

Deep orange and carnation are two of the classic eye color genes in Drosophila. Here, we demonstrate that Deep orange is part of a protein complex that localizes to endosomal compartments. A second component of this complex is Carnation, a homolog of Sec1p-like regulators of membrane fusion. Because complete loss of deep orange function is lethal, the role of this complex in intracellular trafficking was analyzed in deep orange mutant clones. Retinal cells devoid of deep orange function completely lacked pigmentation and exhibited exaggerated multivesicular structures. Furthermore, a defect in endocytic trafficking was visualized in developing photoreceptor cells. These results provide direct evidence that eye color mutations of the granule group also disrupt vesicular trafficking to lysosomes.

Pubmed ID: 10549280 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Carrier Proteins | DNA-Binding Proteins | Drosophila | Drosophila Proteins | Endosomes | Eye Color | Eye Proteins | Fluorescent Antibody Technique | Fungal Proteins | Insect Proteins | Lysosomes | Microscopy, Fluorescence | Molecular Sequence Data | Mutation | Photoreceptor Cells, Invertebrate | Saccharomyces cerevisiae Proteins | Vesicular Transport Proteins

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Associated grants

  • Agency: NEI NIH HHS, Id: EY10199
  • Agency: NEI NIH HHS, Id: R01 EY010199

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