Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.

Cell | Sep 3, 1999

http://www.ncbi.nlm.nih.gov/pubmed/10490100

SOCS1 is an SH2-containing protein that is primarily expressed in thymocytes in a cytokine- and T cell receptor-independent manner. SOCS1 deletion causes perinatal lethality with death by 2-3 weeks. During this period thymic changes include a loss of cellularity and a switch from predominantly CD4+ CD8+ to single positive cells. Peripheral T cells express activation antigens and proliferate to IL-2 in the absence of anti-CD3. In addition, IFNgamma is present in the serum. Reconstitution of the lymphoid lineage of JAK3-deficient mice with SOCS1-deficient stem cells recapitulates the lethality and T cell alterations. Introducing a RAG2 or IFNgamma deficiency eliminates lethality. The results demonstrate that lymphocytes are critical to SOCS1-associated perinatal lethality and implicate SOCS1 in lymphocyte differentiation or regulation.

Pubmed ID: 10490100 RIS Download

Mesh terms: Age Factors | Animals | Animals, Newborn | Carrier Proteins | DNA-Binding Proteins | Dose-Response Relationship, Drug | Flow Cytometry | Gene Expression Regulation, Developmental | Interferon-gamma | Janus Kinase 3 | Lymphocytes | Mice | Mice, Mutant Strains | Protein-Tyrosine Kinases | Repressor Proteins | Suppressor of Cytokine Signaling Proteins | T-Lymphocytes | Thymus Gland | Tissue Distribution

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NCI NIH HHS, Id: CA21765
  • Agency: NHLBI NIH HHS, Id: P01 HL53749
  • Agency: NIDDK NIH HHS, Id: R01 DK42932

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.