Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes.

Molecular cell | Jun 16, 1999

http://www.ncbi.nlm.nih.gov/pubmed/10394363

Insulin-stimulated glucose transport and GLUT4 translocation require regulated interactions between the v-SNARE, VAMP2, and the t-SNARE, syntaxin 4. We have isolated a novel syntaxin 4-binding protein, Synip, which specifically interacts with syntaxin 4. Insulin induces a dissociation of the Synip:syntaxin 4 complex due to an apparent decrease in the binding affinity of Synip for syntaxin 4. In contrast, the carboxyterminal domain of Synip does not dissociate from syntaxin 4 in response to insulin stimulation but inhibits glucose transport and GLUT4 translocation. These data implicate Synip as an insulin-regulated syntaxin 4-binding protein directly involved in the control of glucose transport and GLUT4 vesicle translocation.

Pubmed ID: 10394363 RIS Download

Mesh terms: Adipocytes | Amino Acid Sequence | Animals | Binding, Competitive | Biological Transport | Carrier Proteins | Cell Line | Cloning, Molecular | Cricetinae | Genes, Dominant | Glucose | Glucose Transporter Type 4 | Humans | Insulin | Membrane Proteins | Mice | Molecular Sequence Data | Monosaccharide Transport Proteins | Muscle Proteins | Mutation | Organelles | Protein Binding | Qa-SNARE Proteins | Qb-SNARE Proteins | Qc-SNARE Proteins | R-SNARE Proteins | RNA, Messenger | Vesicular Transport Proteins | Yeasts

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.