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IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.

The interleukin-1 receptor-associated kinase (IRAK) was first described as a signal transducer for interleukin-1 (IL-1) and has later been implicated in signal transduction of other members of the Toll/IL-1 receptor family. We now report the identification and characterization of a novel IRAK-like molecule. In contrast to the ubiquitously expressed IRAK and IRAK-2, this new IRAK-like molecule is found mainly in cells of monomyeloic origin and is, therefore, designated IRAK-M. Although IRAK-M and IRAK-2 exhibit only a negligible autophosphorylation activity, they can reconstitute the IL-1 response in a 293 mutant cell line lacking IRAK. In addition, we show for the first time that members of the IRAK family are indispensable elements of lipopolysaccharide signal transduction. The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family.

Pubmed ID: 10383454


  • Wesche H
  • Gao X
  • Li X
  • Kirschning CJ
  • Stark GR
  • Cao Z


The Journal of biological chemistry

Publication Data

July 2, 1999

Associated Grants


Mesh Terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Antigens, Differentiation
  • Drosophila Proteins
  • Gene Library
  • Humans
  • Interleukin-1 Receptor-Associated Kinases
  • Molecular Sequence Data
  • Myeloid Differentiation Factor 88
  • NF-kappa B
  • Protein Kinases
  • Protein-Serine-Threonine Kinases
  • Proteins
  • Receptors, Immunologic
  • Receptors, Interleukin-1
  • Sequence Alignment
  • Signal Transduction
  • TNF Receptor-Associated Factor 6