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Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression.

This study takes advantage of continuing advances in the precision of magnetic resonance imaging (MRI) to quantify hippocampal volumes in a series of human subjects with a history of depression compared with controls. We sought to test the hypothesis that both age and duration of past depression would be inversely and independently correlated with hippocampal volume. A sample of 24 women ranging in age from 23 to 86 years with a history of recurrent major depression, but no medical comorbidity, and 24 case-matched controls underwent MRI scanning. Subjects with a history of depression (post-depressed) had smaller hippocampal volumes bilaterally than controls. Post-depressives also had smaller amygdala core nuclei volumes, and these volumes correlated with hippocampal volumes. In addition, post-depressives scored lower in verbal memory, a neuropsychological measure of hippocampal function, suggesting that the volume loss was related to an aspect of cognitive functioning. In contrast, there was no difference in overall brain size or general intellectual performance. Contrary to our initial hypothesis, there was no significant correlation between hippocampal volume and age in either post-depressive or control subjects, whereas there was a significant correlation with total lifetime duration of depression. This suggests that repeated stress during recurrent depressive episodes may result in cumulative hippocampal injury as reflected in volume loss.

Pubmed ID: 10366636

Authors

  • Sheline YI
  • Sanghavi M
  • Mintun MA
  • Gado MH

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

June 15, 1999

Associated Grants

  • Agency: NIMH NIH HHS, Id: MH 54731
  • Agency: NIMH NIH HHS, Id: MH 58444
  • Agency: NIMH NIH HHS, Id: MH K07 1370

Mesh Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Amygdala
  • Atrophy
  • Depression
  • Electroconvulsive Therapy
  • Female
  • Hippocampus
  • Humans
  • Hydrocortisone
  • Magnetic Resonance Imaging
  • Menopause
  • Middle Aged
  • Neuropsychological Tests
  • Predictive Value of Tests
  • Time Factors