Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning.

Gene-targeted mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit GluR-A exhibited normal development, life expectancy, and fine structure of neuronal dendrites and synapses. In hippocampal CA1 pyramidal neurons, GluR-A-/- mice showed a reduction in functional AMPA receptors, with the remaining receptors preferentially targeted to synapses. Thus, the CA1 soma-patch currents were strongly reduced, but glutamatergic synaptic currents were unaltered; and evoked dendritic and spinous Ca2+ transients, Ca2+-dependent gene activation, and hippocampal field potentials were as in the wild type. In adult GluR-A-/- mice, associative long-term potentiation (LTP) was absent in CA3 to CA1 synapses, but spatial learning in the water maze was not impaired. The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory.

Pubmed ID: 10364547


  • Zamanillo D
  • Sprengel R
  • Hvalby O
  • Jensen V
  • Burnashev N
  • Rozov A
  • Kaiser KM
  • Köster HJ
  • Borchardt T
  • Worley P
  • Lübke J
  • Frotscher M
  • Kelly PH
  • Sommer B
  • Andersen P
  • Seeburg PH
  • Sakmann B


Science (New York, N.Y.)

Publication Data

June 11, 1999

Associated Grants


Mesh Terms

  • Action Potentials
  • Animals
  • Bicuculline
  • Calcium
  • Dendrites
  • GABA Antagonists
  • Gene Expression
  • Gene Targeting
  • Genes, Immediate-Early
  • Glutamic Acid
  • Hippocampus
  • Long-Term Potentiation
  • Maze Learning
  • Mice
  • Mice, Inbred C57BL
  • Pyramidal Cells
  • Receptors, AMPA
  • Receptors, N-Methyl-D-Aspartate
  • Synapses
  • Synaptic Transmission