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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.

Science (New York, N.Y.) | Apr 23, 1999

The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in most human kidney cancers. The VHL protein is part of a complex that includes Elongin B, Elongin C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination. Here it is shown that the endogenous VHL complex in rat liver also includes Rbx1, an evolutionarily conserved protein that contains a RING-H2 fingerlike motif and that interacts with Cullins. The yeast homolog of Rbx1 is a subunit and potent activator of the Cdc53-containing SCFCdc4 ubiquitin ligase required for ubiquitination of the cyclin-dependent kinase inhibitor Sic1 and for the G1 to S cell cycle transition. These findings provide a further link between VHL and the cellular ubiquitination machinery.

Pubmed ID: 10213691 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Carrier Proteins | Cell Cycle | Cell Cycle Proteins | Cell Line | Cullin Proteins | Cyclin-Dependent Kinase Inhibitor Proteins | F-Box Proteins | Fungal Proteins | Ligases | Liver | Male | Molecular Sequence Data | Peptide Synthases | Proteins | Rats | Rats, Sprague-Dawley | Recombinant Fusion Proteins | S-Phase Kinase-Associated Proteins | SKP Cullin F-Box Protein Ligases | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Sequence Alignment | Transcription Factors | Tumor Suppressor Proteins | Ubiquitin-Protein Ligases | Ubiquitins | Von Hippel-Lindau Tumor Suppressor Protein

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Associated grants

  • Agency: NIA NIH HHS, Id: AG-11085
  • Agency: NIGMS NIH HHS, Id: GM41628

Gene Ontology (Data, Gene Annotation)

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