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Isolation of human delta-catenin and its binding specificity with presenilin 1.

Neuroreport | Feb 25, 1999

We screened proteins for interaction with presenilin (PS) 1, and cloned the full-length cDNA of human delta-catenin, which encoded 1225 amino acids. Yeast two-hybrid assay, GST binding assay and immunoprecipitation demonstrated that delta-catenin interacted with a hydrophilic loop region in the endoproteolytic C-terminal fragment of PS1, but not with that of PS-2. These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1.

Pubmed ID: 10208590 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Armadillo Domain Proteins | COS Cells | Catenins | Cell Adhesion Molecules | Cytoskeletal Proteins | DNA, Complementary | Humans | Membrane Proteins | Molecular Sequence Data | Peptide Fragments | Phosphoproteins | Plakophilins | Precipitin Tests | Presenilin-1 | Presenilin-2 | Substrate Specificity