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Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

Immunity | Mar 23, 1999

The Ikaros gene family encodes zinc finger DNA-binding proteins essential for lineage determination and control of proliferation in the lymphoid system. Here, we report that, in the nucleus of a T cell, a major fraction of Ikaros and Aiolos proteins associate with the DNA-dependent ATPase Mi-2 and histone deacetylases, in a 2 MD complex. This Ikaros-NURD complex is active in chromatin remodeling and histone deacetylation. Upon T cell activation, Ikaros recruits Mi-2/HDAC to regions of heterochromatin. These studies reveal that Ikaros proteins are capable of targeting chromatin remodeling and deacetylation complexes in vivo. We propose that the restructuring of chromatin is a key aspect of Ikaros function in lymphocyte differentiation.

Pubmed ID: 10204490 RIS Download

Mesh terms: Adenosine Triphosphatases | Animals | Autoantigens | Carrier Proteins | Cell Fractionation | Chromatin | DNA Helicases | DNA-Binding Proteins | Drosophila Proteins | G1 Phase | Histone Deacetylases | Ikaros Transcription Factor | Macromolecular Substances | Mice | Mice, Mutant Strains | Nuclear Proteins | Nucleosomes | S Phase | Spleen | T-Lymphocytes | Trans-Activators | Transcription Factors | Zinc Fingers

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Associated grants

  • Agency: PHS HHS, Id: R01
  • Agency: NIAID NIH HHS, Id: R01 AI38342-04

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