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Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

The Ikaros gene family encodes zinc finger DNA-binding proteins essential for lineage determination and control of proliferation in the lymphoid system. Here, we report that, in the nucleus of a T cell, a major fraction of Ikaros and Aiolos proteins associate with the DNA-dependent ATPase Mi-2 and histone deacetylases, in a 2 MD complex. This Ikaros-NURD complex is active in chromatin remodeling and histone deacetylation. Upon T cell activation, Ikaros recruits Mi-2/HDAC to regions of heterochromatin. These studies reveal that Ikaros proteins are capable of targeting chromatin remodeling and deacetylation complexes in vivo. We propose that the restructuring of chromatin is a key aspect of Ikaros function in lymphocyte differentiation.

Pubmed ID: 10204490


  • Kim J
  • Sif S
  • Jones B
  • Jackson A
  • Koipally J
  • Heller E
  • Winandy S
  • Viel A
  • Sawyer A
  • Ikeda T
  • Kingston R
  • Georgopoulos K



Publication Data

March 23, 1999

Associated Grants

  • Agency: PHS HHS, Id: R01
  • Agency: NIAID NIH HHS, Id: R01 AI38342-04

Mesh Terms

  • Adenosine Triphosphatases
  • Animals
  • Autoantigens
  • Carrier Proteins
  • Cell Fractionation
  • Chromatin
  • DNA Helicases
  • DNA-Binding Proteins
  • Drosophila Proteins
  • G1 Phase
  • Histone Deacetylases
  • Ikaros Transcription Factor
  • Macromolecular Substances
  • Mice
  • Mice, Mutant Strains
  • Nuclear Proteins
  • Nucleosomes
  • S Phase
  • Spleen
  • T-Lymphocytes
  • Trans-Activators
  • Transcription Factors
  • Zinc Fingers