Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

A Smad transcriptional corepressor.

Cell | Apr 2, 1999

http://www.ncbi.nlm.nih.gov/pubmed/10199400

Following TGFbeta receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate transcription. We identified the homeodomain protein TGIF as a Smad2-binding protein and a repressor of transcription. A TGFbeta-activated Smad complex can recruit TGIF and histone deacetylases (HDACs) to a Smad target promoter, repressing transcription. Thus, upon entering the nucleus, a Smad2-Smad4 complex may interact with coactivators, forming a transcriptional activation complex, or with TGIF and HDACs, forming a transcriptional repressor complex. Formation of one of these two mutually exclusive complexes is determined by the relative levels of Smad corepressors and coactivators within the cell.

Pubmed ID: 10199400 RIS Download

Mesh terms: Animals | Binding, Competitive | COS Cells | Cells, Cultured | DNA-Binding Proteins | Epithelial Cells | Forkhead Transcription Factors | Histone Deacetylases | Homeodomain Proteins | Lung | Macromolecular Substances | Mink | Nuclear Proteins | Repressor Proteins | Signal Transduction | Smad2 Protein | Trans-Activators | Transcription Factors | Transcription, Genetic | Transforming Growth Factor beta

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NCI NIH HHS, Id: CA34610
  • Agency: NIGMS NIH HHS, Id: GM07739

BioGRID (Data, Interactions)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.