Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene.

Science (New York, N.Y.) | Apr 9, 1999

Phosphorylation of inhibitor of kappa B (IkappaB) proteins is an important step in the activation of the transcription nuclear factor kappa B (NF-kappaB) and requires two IkappaB kinases, IKK1 (IKKalpha) and IKK2 (IKKbeta). Mice that are devoid of the IKK2 gene had extensive liver damage from apoptosis and died as embryos, but these mice could be rescued by the inactivation of the gene encoding tumor necrosis factor receptor 1. Mouse embryonic fibroblast cells that were isolated from IKK2-/- embryos showed a marked reduction in tumor necrosis factor-alpha (TNF-alpha)- and interleukin-1alpha-induced NF-kappaB activity and an enhanced apoptosis in response to TNF-alpha. IKK1 associated with NF-kappaB essential modulator (IKKgamma/IKKAP1), another component of the IKK complex. These results show that IKK2 is essential for mouse development and cannot be substituted with IKK1.

Pubmed ID: 10195897 RIS Download

Mesh terms: Animals | Apoptosis | Cell Line | DNA-Binding Proteins | Embryonic and Fetal Development | Gene Targeting | I-kappa B Kinase | I-kappa B Proteins | Interleukin-1 | Liver | Mice | NF-kappa B | Phosphorylation | Polymerase Chain Reaction | Protein-Serine-Threonine Kinases | Receptors, Tumor Necrosis Factor | Recombinant Fusion Proteins | Sequence Deletion | Signal Transduction | Transcription Factor RelA | Transcription Factors | Tumor Necrosis Factor-alpha

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants


Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.