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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

Science (New York, N.Y.) | Mar 5, 1999

http://www.ncbi.nlm.nih.gov/pubmed/10066179

Protein tyrosine phosphatase-1B (PTP-1B) has been implicated in the negative regulation of insulin signaling. Disruption of the mouse homolog of the gene encoding PTP-1B yielded healthy mice that, in the fed state, had blood glucose concentrations that were slightly lower and concentrations of circulating insulin that were one-half those of their PTP-1B+/+ littermates. The enhanced insulin sensitivity of the PTP-1B-/- mice was also evident in glucose and insulin tolerance tests. The PTP-1B-/- mice showed increased phosphorylation of the insulin receptor in liver and muscle tissue after insulin injection in comparison to PTP-1B+/+ mice. On a high-fat diet, the PTP-1B-/- and PTP-1B+/- mice were resistant to weight gain and remained insulin sensitive, whereas the PTP-1B+/+ mice rapidly gained weight and became insulin resistant. These results demonstrate that PTP-1B has a major role in modulating both insulin sensitivity and fuel metabolism, thereby establishing it as a potential therapeutic target in the treatment of type 2 diabetes and obesity.

Pubmed ID: 10066179 RIS Download

Mesh terms: Animals | Blood Glucose | Diabetes Mellitus, Type 2 | Dietary Fats | Gene Targeting | Glucose Tolerance Test | Insulin | Insulin Receptor Substrate Proteins | Insulin Resistance | Liver | Male | Mice | Mice, Knockout | Muscle, Skeletal | Obesity | Phosphoproteins | Phosphorylation | Phosphotyrosine | Protein Tyrosine Phosphatases | Receptor, Insulin | Signal Transduction

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