SciCrunch Registry/resources/Tools/searchResource NamedbNSFPProper CitationdbNSFP (RRID:SCR_005178)AbbreviationsdbNSFPResource Typedata or information resource, databaseDescriptionA database for functional prediction and annotation of all potential non-synonymous single-nucleotide variants (nsSNVs) in the human genome. Version 2.0 is based on the Gencode release 9 / Ensembl version 64 and includes a total of 87,347,043 nsSNVs and 2,270,742 essential splice site SNVs. It compiles prediction scores from six prediction algorithms (SIFT, Polyphen2, LRT, MutationTaster, MutationAssessor and FATHMM), three conservation scores (PhyloP, GERP++ and SiPhy) and other related information including allele frequencies observed in the 1000 Genomes Project phase 1 data and the NHLBI Exome Sequencing Project, various gene IDs from different databases, functional descriptions of genes, gene expression and gene interaction information, etc. Some dbNSFP contents (may not be up-to-date though) can also be accessed through variant tools, ANNOVAR, KGGSeq, UCSC Genome Browser''s Variant Annotation Integrator, Ensembl Variant Effect Predictor and HGMD.Keywordsnon-synonymous single-nucleotide variant, function, annotation, functional prediction, non-synonymous mutation, splice site mutation, FASEB listResource Relationshipsis used by::Exomiser::SCR_002192; is listed by::OMICtools::SCR_002250; has parent organization::University of Texas Health Science Center at Houston; Texas; USA::SCR_011721; has parent organization::Google Sites::SCR_000112Related ConditionFundingDefining CitationPMID:23843252, PMID:21520341AvailabilityAcknowledgement requested, Free, PublicSpecification URLAlternate IDsOMICS_00172Alternate URLsOld URLsParent OrganizationResource IDSCR_005178SynonymsLicenseLicense URLsRecord Last Update20260801T190927+0000Record Creation Time20220129T080228+0000Mentions Count648v_uuidb3f5fc08-2c45-58f2-b866-960aaf155029Publications that use this research resourcePMID:39938519PMID:39992227PMID:39865314PMID:40113603PMID:40386434PMID:40462930PMID:40692712PMID:40205036PMID:40188234PMID:40247433PMID:40240483PMID:39988467PMID:40923359PMID:41286104PMID:41298473PMID:39762492PMID:39917307PMID:40764308PMID:40813450PMID:40301690PMID:40391866PMID:40624478PMID:40693979PMID:41022857PMID:40021654PMID:40744518PMID:40419521PMID:40325286PMID:40185916PMID:40169570PMID:40377094PMID:40514726PMID:41168175PMID:41193417PMID:40119478PMID:39746940PMID:39747595PMID:40264194PMID:40328947PMID:40439726PMID:40407611PMID:40785186PMID:40890099PMID:40832239PMID:41000875PMID:41414879PMID:41331090PMID:41296379PMID:40533849PMID:40623177PMID:40866546PMID:40702517PMID:40319055PMID:40205335PMID:40593079PMID:40585105PMID:40586332PMID:40093128PMID:39720292PMID:39757988PMID:40375077PMID:41255976PMID:41123735PMID:41149818PMID:39321216PMID:38211594PMID:38255267PMID:39210597PMID:39107301PMID:39180133PMID:39045318PMID:38962751PMID:38785549PMID:38874808PMID:39715278PMID:39688912PMID:38600112PMID:39451534PMID:37956311PMID:38444278PMID:38278947PMID:38469147PMID:39252907PMID:39256839PMID:39137147PMID:39430403PMID:38863077PMID:39840282PMID:39767570PMID:37962568PMID:38534884PMID:38444585PMID:38645242PMID:38763942PMID:39135118PMID:39859960PMID:39606337PMID:38572921PMID:39749016PMID:38849565