Integrated Animals/resources/Organisms/searchOrganism NameB6.129S6-<i>Stat5a/Stat5b^tm2Mam</i>/MmjaxProper CitationRRID:MMRRC_032053-JAXSpeciesMus musculusSynonymsNotesResearch areas: ; Mutation Type: Targeted Mutation ; Collection: Phenotypedecreased hematocrit [MP:0000208]| decreased leukocyte cell number [MP:0000221]| decreased neutrophil cell number [MP:0000222]| decreased monocyte cell number [MP:0000223]| decreased cell proliferation [MP:0000352]| abnormal branching of the mammary ductal tree [MP:0000662]| enlarged spleen [MP:0000691]| decreased body length [MP:0001258]| obese [MP:0001261]| decreased body weight [MP:0001262]| polyphagia [MP:0001433]| increased circulating triglyceride level [MP:0001552]| increased circulating free fatty acid level [MP:0001554]| anemia [MP:0001577]| increased circulating insulin level [MP:0002079]| no abnormal phenotype detected [MP:0002169]| abnormal lymphopoiesis [MP:0002401]| abnormal neutrophil differentiation [MP:0002415]| abnormal proerythroblast morphology [MP:0002416]| abnormal neutrophil physiology [MP:0002463]| abnormal acute inflammation [MP:0002498]| reticulocytosis [MP:0002640]| anisocytosis [MP:0002642]| poikilocytosis [MP:0002643]| microcytosis [MP:0002813]| decreased hemoglobin content [MP:0002874]| decreased erythrocyte cell number [MP:0002875]| decreased insulin secretion [MP:0003059]| abnormal milk ejection [MP:0003838]| abnormal T cell subpopulation ratio [MP:0003944]| increased lean body mass [MP:0003960]| decreased lean body mass [MP:0003961]| decreased circulating insulin-like growth factor I level [MP:0004701]| decreased lymphocyte cell number [MP:0005016]| decreased oxygen consumption [MP:0005290]| impaired glucose tolerance [MP:0005293]| insulin resistance [MP:0005331]| abnormal fat pad morphology [MP:0005334]| increased percent body fat/body weight [MP:0005458]| abnormal leukopoiesis [MP:0005460]| increased circulating glucose level [MP:0005559]| decreased mean corpuscular hemoglobin [MP:0005562]| increased circulating leptin level [MP:0005669]| increased apoptosis [MP:0006042]| abnormal mammary gland growth during lactation [MP:0006270]| abnormal CD4-positive T cell differentiation [MP:0008076]| decreased CD8-positive [MP:0008079]| alpha-beta T cell number [MP:0008388]| hypochromic microcytic anemia [MP:0008614]| increased circulating interleukin-17 level [MP:0008681]| increased interleukin-17 secretion [MP:0008807]| increased liver iron level [MP:0008810]| increased circulating iron level [MP:0008908]| increased total fat pad weight [MP:0008973]| decreased erythroid progenitor cell number [MP:0009254]| disorganized pancreatic islets [MP:0009506]| abnormal mammary gland alveolus morphology [MP:0010024]| increased total body fat amount [MP:0010067]| increased red blood cell distribution width [MP:0010172]| abnormal mammary gland epithelium physiology [MP:0010249]| lactation failure [MP:0011049]| impaired adaptive thermogenesis [MP:0014126]Affected GeneStat5aGenomic AlterationCat Num032053-JAXBackgroundTargeted MutationDatabase NameMutant Mouse Resource and Research Center (MMRRC)DatabaseMMRRCAvailabilitySource ReferencesPMID: 15340066Alternate IDsMMRRC_32053-JAX, MMRRC_032053, MMRRC_3253AuthorityMMRRCRecord Last Update20261010T132411+0000Record Creation Time20230308T055126+0000Mentions Count3v_uuidf4477058-8243-5e9b-8e73-e2925681ec3bPublications that use this research resourcePMID:38091951PMID:34794959PMID:27879203