URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=435
Proper Citation: RRID:MMRRC_000435-UNC
Description: Mus musculus with name STOCK Ptf1atm1.1(cre)Cvw/Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Diabetes, Endocrine Deficiency; Mutation Type: Targeted Mutation ; Collection: BCBC-Beta Cell Biology Consortium
Phenotype: jaundice [MP:0000611]| enlarged spleen [MP:0000691]| paralysis [MP:0000753]| abnormal cerebellar molecular layer [MP:0000889]| weight loss [MP:0001263]| distended abdomen [MP:0001270]| increased metastatic potential [MP:0001272]| decreased metastatic potential [MP:0001273]| abnormal eye development [MP:0001286]| abnormal retina morphology [MP:0001325]| ataxia [MP:0001393]| impaired coordination [MP:0001405]| abnormal gait [MP:0001406]| abnormal motor coordination/balance [MP:0001516]| hepatic necrosis [MP:0001654]| abnormal pancreas morphology [MP:0001944]| increased tumor incidence [MP:0002020]| premature death [MP:0002083]| abnormal innervation [MP:0002184]| abnormal brain commissure morphology [MP:0002199]| abnormal inhibitory postsynaptic currents [MP:0002945]| increased retinal ganglion cell number [MP:0002983]| abnormal digestive system development [MP:0003119]| abnormal GABAergic neuron morphology [MP:0003245]| abnormal duodenum morphology [MP:0003271]| pancreas fibrosis [MP:0003334]| pancreas cysts [MP:0003336]| chronic pancreas inflammation [MP:0003341]| enlarged pancreas [MP:0003450]| abnormal nervous system morphology [MP:0003632]| absent pancreas [MP:0003655]| abnormal pancreas development [MP:0003934]| small pancreas [MP:0004247]| abnormal synaptic vesicle number [MP:0004792]| abnormal paired-pulse inhibition [MP:0004807]| abnormal thrombosis [MP:0005048]| increased susceptibility to injury [MP:0005165]| abnormal pancreatic islet morphology [MP:0005215]| abnormal amacrine cell morphology [MP:0005240]| abnormal retinal neuronal layer morphology [MP:0006069]| absent amacrine cells [MP:0006095]| absent horizontal cells [MP:0008107]| thick retinal ganglion layer [MP:0008508]| absent retinal inner plexiform layer [MP:0008514]| abnormal synaptic bouton morphology [MP:0008571]| abnormal Purkinje cell differentiation [MP:0008579]| increased pancreas weight [MP:0009108]| abnormal pancreatic duct morphology [MP:0009143]| dilated pancreatic duct [MP:0009144]| abnormal pancreatic acinar cell morphology [MP:0009146]| increased pancreatic ductal adenocarcinoma incidence [MP:0009151]| increased pancreatic intraepithelial neoplasia incidence [MP:0009152]| increased pancreas tumor incidence [MP:0009153]| absent pancreatic acini [MP:0009156]| dilated gallbladder [MP:0009343]| abnormal hepatic portal vein morphology [MP:0010668]| neonatal lethality [MP:0011087]| complete penetrance [MP:0011270]| decreased excitatory postsynaptic current amplitude [MP:0013184]| hemorrhagic ascites [MP:0013221]
Affected Gene: crePtf1a
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)