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Italian researchers Gabriele Chelini, Yuri Bozzi, and colleagues at the University of Trento, Rovereto introduce a new computational tool that uses machine learning and unsupervised cluster analysis via DeepCupLab to automate the analysis of mouse behavior in response to stimuli. Through experimentation, this new tool, named S3BER (imulus-evoked behavioral tracking in 3D for rodents), acts as a valuable and reliable resource for studying emotional responses in mice.
Inverted fluorescence phase contrast microscope. Objective lenses. BZ Series infinite optical system.
Platform provides self service data access, integrated data visualization and analysis and collaboration tools that allow compound prioritization, development of SAR and many other scientific data workflows in chemistry and biology domains to improve effectiveness of data driven research.
Electrophysiology acquisition software, compatible with HEKA EPC amplifiers.
Device used for measuring blood glucose levels.
Apparatus used for measuring mice licking pattern for particular solutions. Device records licking behavior by measuring number of licks per second , which is drawn as bar graph on the PC software screen .
Apparatus set for measuring animal movement activity using beam sensor
ICDS brings researchers together to develop and apply innovative, high performance computation methods. Helps to apply big data and big simulation methods across research landscape.
Aims to foster collaborative, interdisciplinary research across Penn State and beyond aimed at addressing the AI grand challenge of accelerating scientific progress through synergistic advances across multiple areas of AI.
Core provides expertise and high frequency ultrasound instrumentation suitable for image acquisition and analysis applicable to your research studies. Provides Fuji/Visualsonics Vevo 3100 ultrasound imaging machine to perform ultrasounds on small animals. The scanner has high temporal and spatial resolution; current imaging probes utilize frequencies from 13-55 MHz.
Core provides technical expertise, advice, and training and is comprised of three functional sections: Molecular cloning (plasmid, virus, CRISPR/Cas9); Viral vectors (lentivirus, adenovirus, adeno-associated virus); Animal services (transgenic, knockout, cryopreservation, re-derivation, and more). Services offered include Assistance for generating recombinant plasmids; Design and implementation of CRISPR/Cas9 technology for in vivo and in vitro work; Mouse and rat transgenesis,including transgenic and knockout/knockdown techniques using pronuclear injection, ES cell injection/chimera, and CRISPR/Cas9-mediated genome editing; Production of lentivirus, adenovirus, and adeno-associated virus vectors; Additional animal testing and procedures: teratoma and chimera testing to validate putative pluripotent stem cell lines, cryopreserve or re-derive of valuable transgenic lines (sperm or embryos).
Dragonfly is a brand of Comet Technologies Canada Inc. Company develops applications to better understand image data. Providews advanced 3D visualization and analysis software for 2D, 3D, and 4D imaging studies.
Hosted drug discovery informatics platform that securely manages both private and external biological and chemical data. Provides core functionality including chemical registration, structure activity relationship, chemical inventory, and electronic lab notebook capabilities.
Web tool for prediction of sgRNAs. Helps to select optimal guide RNA for gene of interest. Support for designing guide libraries. CRISPick ranks and picks candidate CRISPRko sgRNA sequences for targets provided, while attempting to maximize on-target activity and minimizing off-target activity.
Metabolic stress testing system provides breath by breath metabolic analysis during both rest and exercise for complete assessment of functional capacity and cardiorespiratory diagnostics.Testing capabilities including Exercise Capacity,Direct Fick Cardiac Output and Spirometry.
System that combines proprietary 10x microfluidics technology using Chromium Automated Controller with precise, automated liquid handling that allows users to run 10x Genomics end to end library construction workflow with minimal user interaction. Integrates components customized for 10x Genomics single cell workflows, automation specific reagents and consumables, and touchscreen computer. Used to generate consistent and reproducible single cell gene expression results across experiments, users, and multiple sites.
One of several isotope labs in Department of Geology and Environmental Science formerly known as Regional Stable Isotope Lab for Earth and Environmental Science Research, has capacity for wide variety of isotopic measurements in multitude of sample media. Capabilities include: Nitrate (?15N, ?18O, D17O);Greenhouse and trace gases like carbon dioxide (?13C, ?18O), nitrous oxide (?15N, ?18O), methane (?13C); Nitrogen, carbon, and sulfur (?15N, ?13C, ?34S) in organic and other solid materials (e.g., biota, soils);Ammonium (?15N); Dry reactive nitrogen deposition (?15N-NH3, ?15-NO2, and ?15N-HNO3); and Carbonates (?13C, ?18O).
Database of theoretical and confirmed HLA eplets recognizable by B-Cell receptors. Eplets are sorted according to their amino acid sequence positions. Used for identifying HLA epitopes.
crystal structure files for biomolecules
Database of predicted three dimensional structures of Human Leukocyte Antigens molecules constructed by using homology modeling. Developed to improve epitope analysis in context of organ transplantation by providing 3D structures of HLA molecules present in current solid-phase assays for serum antibodies screening. Gives crystalographic modeling structure of HLA protein.Provides means to visualize target epitopes recognized by anti-HLA antibodies.